/* Doctor KLOW — Flat Design Informativo Claro
 * Source Sans 3 + IBM Plex Sans Condensed + IBM Plex Mono
 * Pure white + light-gray section bands. Four-category vivid palette as strict
 * component taxonomy. Red CC0000 reserved for active nav, citation markers, CTAs.
 */

:root {
  /* Palette */
  --primary: #001F3F;
  --primary-50: #E6EAF0;
  --primary-100: #C2CCDA;
  --primary-700: #00152C;
  --primary-900: #000A17;
  --secondary: #333333;
  --accent: #CC0000;
  --accent-hover: #A60000;
  --neutral-50: #FFFFFF;
  --neutral-100: #F5F5F5;
  --neutral-200: #E8E8E8;
  --neutral-300: #D0D0D0;
  --neutral-500: #777777;
  --neutral-700: #333333;
  --neutral-900: #1A1A1A;
  --bg: #FFFFFF;
  --bg-alt: #F5F5F5;
  --surface: #FFFFFF;
  --surface-alt: #F5F5F5;
  --text: #333333;
  --text-strong: #001F3F;
  --text-muted: #777777;
  --text-inverse: #FFFFFF;
  --rule: #E8E8E8;
  --rule-strong: #333333;
  --rule-accent: #CC0000;

  /* Component category colors */
  --cat-kpv: #2ECC40;
  --cat-ghkcu: #FFD700;
  --cat-bpc157: #FF8C00;
  --cat-tb500: #001F3F;

  /* Evidence chip colors */
  --evi-human: #2ECC40;
  --evi-preclin: #FF8C00;
  --evi-none: #CC0000;

  /* Layout */
  --max-width: 76rem;
  --container-px: clamp(1rem, 3vw, 2rem);

  /* Type */
  --font-heading: 'Source Sans 3', 'Helvetica Neue', Arial, system-ui, -apple-system, sans-serif;
  --font-body: 'Source Sans 3', system-ui, -apple-system, 'Segoe UI', sans-serif;
  --font-cond: 'IBM Plex Sans Condensed', 'Roboto Condensed', 'Helvetica Neue Condensed', Arial Narrow, sans-serif;
  --font-mono: 'IBM Plex Mono', 'SF Mono', Menlo, Consolas, monospace;

  /* Radii */
  --r-button: 6px;
  --r-card: 6px;
  --r-pill: 9999px;

  /* Transitions */
  --t-fast: 180ms ease-out;
}

/* Reset */
*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0;
  font-family: var(--font-body);
  font-size: 1.0625rem;
  line-height: 1.65;
  color: var(--text);
  background: var(--bg);
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
img, svg { max-width: 100%; height: auto; display: block; }
a { color: var(--text); text-decoration: none; transition: color var(--t-fast); }
a:hover { color: var(--accent); }
button { font: inherit; }

/* Headings */
h1, h2, h3, h4, h5, h6 {
  font-family: var(--font-heading);
  color: var(--text-strong);
  line-height: 1.15;
  margin: 0 0 0.65em;
}
h1 {
  font-weight: 900;
  font-size: clamp(2.25rem, 4.75vw, 3.5rem);
  letter-spacing: -0.015em;
}
h2 {
  font-weight: 700;
  font-size: clamp(1.625rem, 3vw, 2.25rem);
  letter-spacing: -0.01em;
  margin-top: 2.25rem;
}
h3 {
  font-weight: 700;
  font-size: 1.25rem;
  margin-top: 1.75rem;
}
h4 {
  font-weight: 600;
  font-size: 1.0625rem;
}
p { margin: 0 0 1em; }
p.lead {
  font-size: 1.1875rem;
  line-height: 1.55;
  max-width: 60ch;
}
strong { font-weight: 700; color: var(--text-strong); }
em { font-style: italic; }
ul, ol { margin: 0 0 1em; padding-left: 1.5rem; }
li { margin-bottom: 0.4em; }

/* Eyebrow + category tag text */
.eyebrow {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  line-height: 1.2;
  color: var(--accent);
  margin: 0 0 0.75rem;
}
.eyebrow--muted { color: var(--text-muted); }
.eyebrow--navy { color: var(--text-strong); }

/* Container */
.container {
  max-width: var(--max-width);
  margin: 0 auto;
  padding-left: var(--container-px);
  padding-right: var(--container-px);
}

/* Masthead */
.site-header {
  background: var(--neutral-50);
  border-bottom: 1px solid var(--neutral-200);
}
.site-header .container {
  display: flex;
  align-items: center;
  gap: 1.25rem;
  height: 64px;
}
.site-brand {
  display: inline-flex;
  align-items: center;
  gap: 0.625rem;
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.125rem;
  color: var(--text-strong);
  letter-spacing: -0.005em;
}
.brand-mark {
  width: 24px;
  height: 24px;
  display: grid;
  grid-template-columns: 1fr 1fr;
  grid-template-rows: 1fr 1fr;
  gap: 2px;
  flex-shrink: 0;
}
.brand-mark span { display: block; }
.brand-mark span:nth-child(1) { background: var(--cat-kpv); }
.brand-mark span:nth-child(2) { background: var(--cat-ghkcu); }
.brand-mark span:nth-child(3) { background: var(--cat-bpc157); }
.brand-mark span:nth-child(4) { background: var(--cat-tb500); }

.site-nav {
  flex: 1;
  display: none;
}
.site-nav ul {
  list-style: none;
  margin: 0;
  padding: 0;
  display: flex;
  gap: 1.5rem;
  justify-content: center;
}
.site-nav li { margin: 0; }
.site-nav a {
  display: inline-block;
  font-family: var(--font-body);
  font-weight: 500;
  font-size: 0.9375rem;
  color: var(--text);
  padding: 0.25rem 0;
  position: relative;
  transition: color var(--t-fast);
}
.site-nav a:hover { color: var(--accent); }
.site-nav a[aria-current="page"] {
  color: var(--text-strong);
}
.site-nav a[aria-current="page"]::after {
  content: "";
  position: absolute;
  left: 0; right: 0;
  bottom: -8px;
  height: 3px;
  background: var(--accent);
}

.header-meta {
  display: none;
  align-items: center;
  gap: 0.75rem;
  margin-left: auto;
}
.header-meta .icon-btn {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 32px; height: 32px;
  border: 1px solid var(--neutral-200);
  border-radius: 6px;
  background: var(--neutral-50);
  color: var(--text);
  cursor: pointer;
  transition: border-color var(--t-fast), color var(--t-fast);
}
.header-meta .icon-btn:hover { border-color: var(--accent); color: var(--accent); }
.header-meta .ruo-chip {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.6875rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--accent);
  border: 1px solid var(--accent);
  border-radius: var(--r-pill);
  padding: 0.25rem 0.625rem;
  line-height: 1;
}

.mobile-toggle {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 36px; height: 36px;
  margin-left: auto;
  background: var(--neutral-50);
  border: 1px solid var(--neutral-200);
  border-radius: 6px;
  cursor: pointer;
  color: var(--text);
}

@media (min-width: 960px) {
  .site-nav { display: flex; align-items: center; }
  .header-meta { display: inline-flex; }
  .mobile-toggle { display: none; }
}

.mobile-nav {
  display: none;
  border-top: 1px solid var(--neutral-200);
  background: var(--neutral-50);
}
.mobile-nav.open { display: block; }
.mobile-nav ul {
  list-style: none;
  margin: 0;
  padding: 0.5rem var(--container-px) 1rem;
}
.mobile-nav li { margin: 0; }
.mobile-nav a {
  display: block;
  padding: 0.625rem 0;
  font-family: var(--font-body);
  font-weight: 500;
  font-size: 1rem;
  border-bottom: 1px solid var(--neutral-200);
}
.mobile-nav a[aria-current="page"] { color: var(--accent); }

/* Breadcrumb */
.breadcrumb {
  font-family: var(--font-cond);
  font-weight: 500;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text);
  padding: 1rem 0 0;
}
.breadcrumb ol {
  list-style: none;
  margin: 0;
  padding: 0;
  display: flex;
  flex-wrap: wrap;
  gap: 0.5rem;
  align-items: center;
}
.breadcrumb li { margin: 0; display: inline-flex; align-items: center; gap: 0.5rem; }
.breadcrumb li + li::before {
  content: ">";
  color: var(--accent);
  font-weight: 700;
}
.breadcrumb a { color: var(--text); transition: color var(--t-fast); }
.breadcrumb a:hover { color: var(--accent); }
.breadcrumb [aria-current="page"] { color: var(--text-strong); }

/* Hero */
.hero {
  padding: 2.5rem 0 1.5rem;
}
.hero-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 2rem;
  align-items: start;
}
.hero-readtime {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-top: 1rem;
}
.hero-figure {
  margin: 0;
}
.hero-figure img {
  width: 100%;
  height: auto;
  border-radius: 6px;
}

@media (min-width: 1024px) {
  .hero { padding: 3.5rem 0 2rem; }
  .hero-grid {
    grid-template-columns: 7fr 5fr;
    gap: 3rem;
  }
}

/* Buttons */
.cta-row {
  display: flex;
  flex-wrap: wrap;
  gap: 0.875rem;
  margin: 1.5rem 0 0;
}
.btn {
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  padding: 0.75rem 1.375rem;
  font-family: var(--font-body);
  font-weight: 600;
  font-size: 0.9375rem;
  line-height: 1.2;
  border-radius: var(--r-button);
  border: 1.5px solid transparent;
  cursor: pointer;
  transition: background-color var(--t-fast), border-color var(--t-fast), color var(--t-fast), transform 80ms ease-out;
}
.btn-primary {
  background: var(--accent);
  color: var(--text-inverse);
  border-color: var(--accent);
}
.btn-primary:hover {
  background: var(--accent-hover);
  border-color: var(--accent-hover);
  color: var(--text-inverse);
}
.btn-primary:active { transform: scale(0.98); }
.btn-secondary {
  background: transparent;
  color: var(--text-strong);
  border-color: var(--text-strong);
}
.btn-secondary:hover {
  background: var(--primary-50);
  color: var(--text-strong);
}
.btn-ghost {
  background: transparent;
  color: var(--text);
  border-color: transparent;
  padding: 0.5rem 0.25rem;
  position: relative;
}
.btn-ghost::after {
  content: "";
  position: absolute;
  left: 0.25rem; right: 0.25rem;
  bottom: 0.35rem;
  height: 1px;
  background: transparent;
  transition: background var(--t-fast);
}
.btn-ghost:hover { color: var(--accent); }
.btn-ghost:hover::after { background: var(--accent); }

:focus-visible {
  outline: 2px solid var(--accent);
  outline-offset: 3px;
}
.btn-primary:focus-visible {
  outline-color: var(--neutral-50);
  box-shadow: 0 0 0 4px var(--accent);
}

/* Section bands */
section.band {
  background: var(--neutral-100);
  padding: 3rem 0;
  margin: 2.5rem 0;
}

/* Cards */
.card {
  background: var(--neutral-50);
  border: 1px solid var(--neutral-200);
  border-radius: var(--r-card);
  padding: 1.5rem;
  position: relative;
  overflow: hidden;
}
.card::before {
  content: "";
  position: absolute;
  top: 0; left: 0; right: 0;
  height: 4px;
  background: var(--accent);
  transition: height var(--t-fast);
}
.card:hover::before { height: 6px; }
.card.no-bar::before { display: none; }
.card .card-eyebrow {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.6875rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin: 0 0 0.5rem;
}
.card h3, .card .card-title {
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.125rem;
  color: var(--text-strong);
  margin: 0 0 0.5rem;
}
.card .card-body {
  font-size: 0.9375rem;
  color: var(--text);
  margin: 0;
}

/* Category-coded cards */
.card.cat-kpv::before { background: var(--cat-kpv); }
.card.cat-ghkcu::before { background: var(--cat-ghkcu); }
.card.cat-bpc157::before { background: var(--cat-bpc157); }
.card.cat-tb500::before { background: var(--cat-tb500); }
.card.cat-callout::before { background: var(--accent); }

.card .card-eyebrow.cat-kpv { color: var(--cat-kpv); }
.card .card-eyebrow.cat-ghkcu { color: #8B6F00; } /* gold has poor contrast — bump darker for label */
.card .card-eyebrow.cat-bpc157 { color: #B85F00; }
.card .card-eyebrow.cat-tb500 { color: var(--cat-tb500); }
.card .card-eyebrow.cat-callout { color: var(--accent); }

/* Component card grid */
.component-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 1.25rem;
}
@media (min-width: 640px) {
  .component-grid { grid-template-columns: 1fr 1fr; }
}
@media (min-width: 1024px) {
  .component-grid { grid-template-columns: repeat(4, 1fr); }
}
.component-card {
  background: var(--neutral-50);
  border: 1px solid var(--neutral-200);
  border-radius: var(--r-card);
  padding: 1.5rem;
  position: relative;
  overflow: hidden;
  display: flex;
  flex-direction: column;
  gap: 0.65rem;
}
.component-card::before {
  content: "";
  position: absolute;
  top: 0; left: 0; right: 0;
  height: 4px;
  transition: height var(--t-fast);
}
.component-card.cat-kpv::before { background: var(--cat-kpv); }
.component-card.cat-ghkcu::before { background: var(--cat-ghkcu); }
.component-card.cat-bpc157::before { background: var(--cat-bpc157); }
.component-card.cat-tb500::before { background: var(--cat-tb500); }
.component-card:hover::before { height: 6px; }

.cat-icon {
  width: 32px;
  height: 32px;
  border-radius: 50%;
  display: inline-flex;
  align-items: center;
  justify-content: center;
  color: #FFFFFF;
  flex-shrink: 0;
}
.cat-icon.cat-kpv { background: var(--cat-kpv); }
.cat-icon.cat-ghkcu { background: var(--cat-ghkcu); color: #001F3F; }
.cat-icon.cat-bpc157 { background: var(--cat-bpc157); }
.cat-icon.cat-tb500 { background: var(--cat-tb500); }
.cat-icon svg, .cat-icon i {
  width: 18px; height: 18px;
}

.component-card .row {
  display: flex;
  align-items: center;
  gap: 0.75rem;
}
.component-card .name {
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.0625rem;
  color: var(--text-strong);
  margin: 0;
  line-height: 1.2;
}
.component-card .tag {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.6875rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin: 0;
}
.component-card .summary {
  font-size: 0.9375rem;
  color: var(--text);
  margin: 0;
}
.component-card .read-more {
  font-family: var(--font-body);
  font-weight: 600;
  font-size: 0.875rem;
  color: var(--accent);
  display: inline-flex;
  align-items: center;
  gap: 0.25rem;
  margin-top: auto;
}
.component-card .read-more:hover { color: var(--accent-hover); }

/* Category tag chip (filled) */
.cat-tag {
  display: inline-flex;
  align-items: center;
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.6875rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: #FFFFFF;
  border-radius: var(--r-pill);
  padding: 0.2rem 0.625rem;
  line-height: 1.2;
}
.cat-tag.cat-kpv { background: var(--cat-kpv); }
.cat-tag.cat-ghkcu { background: var(--cat-ghkcu); color: var(--text-strong); }
.cat-tag.cat-bpc157 { background: var(--cat-bpc157); }
.cat-tag.cat-tb500 { background: var(--cat-tb500); }

/* Evidence chip (border-only) */
.evi-chip {
  display: inline-flex;
  align-items: center;
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.6875rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  background: var(--neutral-50);
  border: 1px solid currentColor;
  border-radius: var(--r-pill);
  padding: 0.2rem 0.625rem;
  line-height: 1.2;
}
.evi-chip.evi-human { color: #1C9A2B; }
.evi-chip.evi-preclin { color: #B85F00; }
.evi-chip.evi-none { color: var(--accent); }

/* Inline component dot */
.cdot {
  display: inline-block;
  width: 0.5em;
  height: 0.5em;
  border-radius: 50%;
  margin-right: 0.2em;
  vertical-align: 0.05em;
}
.cdot.cat-kpv { background: var(--cat-kpv); }
.cdot.cat-ghkcu { background: var(--cat-ghkcu); }
.cdot.cat-bpc157 { background: var(--cat-bpc157); }
.cdot.cat-tb500 { background: var(--cat-tb500); }

/* Citation marker */
sup.cite {
  font-size: 0.6875rem;
  line-height: 0;
  margin-left: 0.05em;
}
sup.cite a, a.cite {
  color: var(--accent);
  font-weight: 600;
  text-decoration: none;
  cursor: pointer;
}
sup.cite a:hover, a.cite:hover { color: var(--accent-hover); }

/* Page content layout */
.page-body {
  display: grid;
  grid-template-columns: 1fr;
  gap: 2rem;
  padding: 2rem 0 3rem;
}
.page-body > article { min-width: 0; }
.page-body .article {
  max-width: 66ch;
}
.page-body .article p { font-size: 1.0625rem; }
.page-body section { margin-top: 2.5rem; }
.page-body section:first-child { margin-top: 1rem; }

.page-body figure {
  margin: 1.75rem 0;
}
.page-body figure img {
  width: 100%;
  border-radius: 6px;
}
.page-body figcaption {
  font-family: var(--font-cond);
  font-weight: 500;
  font-size: 0.75rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-top: 0.5rem;
}

.section-rule {
  border: 0;
  border-top: 1px solid var(--neutral-200);
  margin: 2.25rem 0;
}

/* Category rail (right sidebar on long pages) */
.cat-rail {
  display: none;
}
@media (min-width: 1024px) {
  .page-body.has-rail {
    grid-template-columns: minmax(0, 8fr) minmax(0, 4fr);
  }
  .cat-rail {
    display: block;
    position: sticky;
    top: 84px;
    align-self: start;
  }
}
.cat-rail h4 {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin: 0 0 0.5rem;
}
.cat-rail ul {
  list-style: none;
  margin: 0 0 1.5rem;
  padding: 0;
}
.cat-rail li {
  display: flex;
  align-items: center;
  gap: 0.5rem;
  padding: 0.35rem 0;
  font-size: 0.9375rem;
}
.cat-rail .dot {
  width: 12px; height: 12px;
  flex-shrink: 0;
  border-radius: 2px;
}
.cat-rail .dot.cat-kpv { background: var(--cat-kpv); }
.cat-rail .dot.cat-ghkcu { background: var(--cat-ghkcu); }
.cat-rail .dot.cat-bpc157 { background: var(--cat-bpc157); }
.cat-rail .dot.cat-tb500 { background: var(--cat-tb500); }
.cat-rail .mass {
  font-family: var(--font-cond);
  font-weight: 500;
  font-size: 0.75rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-left: auto;
}
.cat-rail a {
  color: var(--text);
  display: inline-flex;
  align-items: center;
  gap: 0.5rem;
  flex: 1;
}
.cat-rail a:hover { color: var(--accent); }

/* Category-color left rule on H2 within article */
.article h2 {
  position: relative;
  padding-left: 1rem;
  border-left: 4px solid var(--neutral-200);
}
.article h2.cat-kpv { border-left-color: var(--cat-kpv); }
.article h2.cat-ghkcu { border-left-color: var(--cat-ghkcu); }
.article h2.cat-bpc157 { border-left-color: var(--cat-bpc157); }
.article h2.cat-tb500 { border-left-color: var(--cat-tb500); }
.article h2.cat-callout { border-left-color: var(--accent); }

/* Pull quote */
blockquote.pull-quote {
  font-family: var(--font-heading);
  font-weight: 600;
  font-size: 1.5rem;
  line-height: 1.35;
  color: var(--text-strong);
  border-left: 4px solid var(--accent);
  padding: 0.25rem 0 0.25rem 1.5rem;
  margin: 2rem 0;
}
blockquote.pull-quote cite {
  display: block;
  margin-top: 0.75rem;
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  font-style: normal;
  color: var(--text-muted);
}

/* Table */
table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.9375rem;
  margin: 1.5rem 0;
  background: var(--neutral-50);
}
table thead th {
  border-top: 1px solid var(--text-strong);
  border-bottom: 1.5px solid var(--text-strong);
  text-align: left;
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text);
  padding: 0.625rem 1rem;
  white-space: nowrap;
}
table tbody td {
  border-bottom: 1px solid var(--neutral-200);
  padding: 0.625rem 1rem;
  vertical-align: top;
  transition: background var(--t-fast);
}
table tbody tr:hover td { background: var(--neutral-100); }
table .num, table td.num {
  font-family: var(--font-mono);
  font-weight: 500;
  text-align: right;
  white-space: nowrap;
}
table .doi, table td.doi {
  font-family: var(--font-mono);
  font-size: 0.8125rem;
  word-break: break-all;
}

/* Composition bars figure (HTML/CSS — used as a redundant text version under image) */
.composition-bars {
  border: 1px solid var(--text-strong);
  padding: 1rem;
  background: var(--neutral-50);
  border-radius: 6px;
}
.composition-bars h4 {
  margin: 0 0 0.5rem;
  font-size: 1rem;
}
.composition-bars .cbar {
  position: relative;
  height: 28px;
  margin-bottom: 4px;
  color: #fff;
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.6875rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  line-height: 28px;
  padding-left: 0.6rem;
  white-space: nowrap;
  overflow: hidden;
  text-overflow: ellipsis;
}
.composition-bars .cbar.cat-kpv { background: var(--cat-kpv); }
.composition-bars .cbar.cat-ghkcu { background: var(--cat-ghkcu); color: var(--text-strong); }
.composition-bars .cbar.cat-bpc157 { background: var(--cat-bpc157); }
.composition-bars .cbar.cat-tb500 { background: var(--cat-tb500); }

/* Translation Gap callout */
.callout {
  background: var(--neutral-50);
  border: 1px solid var(--neutral-200);
  border-radius: var(--r-card);
  padding: 1.5rem;
  position: relative;
  overflow: hidden;
  margin: 1.75rem 0;
}
.callout::before {
  content: "";
  position: absolute;
  top: 0; left: 0; right: 0;
  height: 4px;
  background: var(--accent);
}
.callout .eyebrow {
  color: var(--accent);
  margin-bottom: 0.5rem;
}
.callout h4 {
  margin: 0 0 0.5rem;
  font-size: 1.125rem;
  color: var(--text-strong);
}
.callout p { margin: 0; font-size: 0.9375rem; }

/* Mono inline (DOI/PMID/dose) */
code, .mono {
  font-family: var(--font-mono);
  font-size: 0.9375rem;
}

/* Forms */
.form-row {
  display: flex;
  flex-direction: column;
  gap: 0.35rem;
  margin-bottom: 1.25rem;
}
.form-row label {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text);
}
.form-row input,
.form-row textarea,
.form-row select {
  font: inherit;
  font-size: 1rem;
  font-family: var(--font-body);
  color: var(--text);
  background: var(--neutral-50);
  border: 1px solid var(--neutral-200);
  border-radius: 6px;
  padding: 0.65rem 0.85rem;
  transition: border-color var(--t-fast);
  width: 100%;
}
.form-row input:focus,
.form-row textarea:focus,
.form-row select:focus {
  outline: none;
  border-color: var(--accent);
  box-shadow: 0 0 0 1px var(--accent);
}
.form-row textarea { min-height: 160px; resize: vertical; }

/* References list (fallback non-table) */
.references-list {
  list-style: none;
  padding: 0;
  counter-reset: ref;
}
.references-list li {
  padding: 0.85rem 0;
  border-bottom: 1px solid var(--neutral-200);
  display: grid;
  grid-template-columns: 2.5rem 1fr;
  gap: 0.75rem;
}
.references-list li::before {
  counter-increment: ref;
  content: "[" counter(ref) "]";
  font-family: var(--font-mono);
  font-weight: 500;
  color: var(--accent);
  font-size: 0.875rem;
  white-space: nowrap;
}

/* Footer */
.site-footer {
  background: var(--neutral-100);
  margin-top: 4rem;
  padding: 2.5rem 0 1.25rem;
}
.footer-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: 1.5rem;
  padding-bottom: 1.5rem;
}
@media (min-width: 720px) {
  .footer-grid { grid-template-columns: repeat(2, 1fr); }
}
@media (min-width: 1024px) {
  .footer-grid { grid-template-columns: repeat(4, 1fr); }
}
.footer-grid h4 {
  font-family: var(--font-cond);
  font-weight: 600;
  font-size: 0.75rem;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--text-strong);
  margin: 0 0 0.65rem;
}
.footer-grid ul { list-style: none; padding: 0; margin: 0; }
.footer-grid li { margin: 0.3rem 0; }
.footer-grid a {
  color: var(--text);
  font-size: 0.9375rem;
  font-weight: 500;
}
.footer-grid a:hover { color: var(--accent); }

.footer-disclosure {
  border-top: 1px solid var(--neutral-200);
  padding: 1.25rem 0;
  font-size: 0.875rem;
  color: var(--text);
}
.footer-disclosure .disclaimer { font-weight: 600; }
.footer-disclosure .colophon {
  font-family: var(--font-cond);
  font-weight: 500;
  font-size: 0.75rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--text-muted);
  margin-top: 0.4rem;
}
.footer-disclosure .build-date {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: var(--text-muted);
}
.footer-copyright {
  border-top: 1px solid var(--text-strong);
  padding-top: 1rem;
  font-size: 0.8125rem;
  color: var(--text-muted);
}

/* Tippy.js custom theme — flat, no shadow */
.tippy-box[data-theme~='doctorklow'] {
  background: var(--neutral-50);
  color: var(--text);
  border: 1px solid var(--neutral-200);
  border-radius: 6px;
  font-family: var(--font-body);
  font-size: 0.8125rem;
  box-shadow: none;
  max-width: 360px !important;
}
.tippy-box[data-theme~='doctorklow'] .tippy-content { padding: 0.65rem 0.8rem; }
.tippy-box[data-theme~='doctorklow'] .tippy-arrow { color: var(--neutral-200); }
.tippy-box[data-theme~='doctorklow'] strong {
  color: var(--text-strong);
  font-family: var(--font-heading);
  font-weight: 600;
  font-size: 0.875rem;
  display: block;
  margin-bottom: 0.25rem;
}
.tippy-box[data-theme~='doctorklow'] .doi {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  color: var(--text-muted);
  display: block;
  margin-top: 0.25rem;
  word-break: break-all;
}

/* DataTables overrides — minimal */
.dataTables_wrapper {
  font-family: var(--font-body);
  font-size: 0.9375rem;
}
.dataTables_wrapper .dataTables_length,
.dataTables_wrapper .dataTables_filter {
  margin: 0.75rem 0;
}
.dataTables_wrapper .dataTables_filter input {
  font: inherit;
  border: 1px solid var(--neutral-200);
  border-radius: 6px;
  padding: 0.4rem 0.65rem;
  margin-left: 0.5rem;
}
.dataTables_wrapper .dataTables_filter input:focus {
  outline: none;
  border-color: var(--accent);
}
.dataTables_wrapper .dataTables_paginate .paginate_button {
  border: 1px solid var(--neutral-200) !important;
  border-radius: 6px !important;
  padding: 0.35rem 0.7rem !important;
  margin: 0 0.15rem !important;
}
.dataTables_wrapper .dataTables_paginate .paginate_button.current {
  background: var(--neutral-50) !important;
  color: var(--accent) !important;
  border-color: var(--accent) !important;
}
.dataTables_wrapper .dataTables_paginate .paginate_button:hover {
  background: var(--neutral-100) !important;
  border-color: var(--accent) !important;
  color: var(--accent) !important;
}
table.dataTable thead th { cursor: pointer; }
table.dataTable thead th:hover { color: var(--accent); }

/* Utility helpers (replace inline styles to honor strict separation) */
.cta-row.is-centered { justify-content: center; }
.form-note { font-size: 0.875rem; color: var(--text-muted); margin-top: 1rem; }
.h-flush { border-left: 0 !important; padding-left: 0 !important; }
.lead.tight { margin-bottom: 1.5rem; }
.article.wide { max-width: 72ch; }
.figure-narrow img { max-width: 480px; margin: 0 auto; }

/* 404 */
.notfound {
  text-align: center;
  padding: 5rem 0;
}
.notfound h1 { font-size: clamp(3rem, 8vw, 5rem); margin-bottom: 0.5rem; }
.notfound p { font-size: 1.0625rem; max-width: 50ch; margin: 0 auto 1.5rem; }

/* Reduced motion */
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after {
    transition-duration: 0ms !important;
    animation-duration: 0ms !important;
    animation-iteration-count: 1 !important;
    scroll-behavior: auto !important;
  }
}

/* Print-friendly tweaks */
@media print {
  .site-header, .site-footer, .cta-row, .cat-rail { display: none; }
  body { color: #000; background: #fff; }
}